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At least 10 people have been injured and shots fired at protests in the Afghan capital Kabul over the burning of copies of the Koran at a US airbase.
Protests are also under way in the eastern city of Jalalabad.
On Tuesday, the US commander in Afghanistan, Gen John Allen, apologised after Korans were "inadvertently" put in an incinerator at Bagram airbase.
US officials reportedly believed Taliban prisoners were using the books to pass messages to each other.
The charred remains of the volumes were found by local labourers.
Protesters in Kabul shouted, "Death to America!" and threw stones at Camp Phoenix, the main US base in the city.
Witnesses at the protests in Kabul said security guards were firing into the air. There are also reports of people chanting pro-Taliban slogans.
Demonstrators blocked the road linking Kabul with Jalalabad, one of the main trade routes into the Afghan capital.
A riot police unit was attacked by protesters in Kabul and fled, the AFP news agency reported.
One protester, 18-year-old Ajmal, told Reuters: "When the Americans insult us to this degree, we will join the insurgents."
The US embassy in Kabul has tweeted that it is on lockdown and all travel is suspended.
US Defence Secretary Leon Panetta said he and Gen Allen apologised to the Afghan people "and disapprove of such conduct in the strongest possible terms".
After previous incidents, many Afghans find it hard to understand how US forces could have allowed the Koran to have been burned, our correspondent says.
Last year, at least 24 people died in protests after a hardline US pastor burned a Koran in Florida.
On Tuesday, one person was wounded and five detained after troops at Bagram, 60km (40 miles) north of Kabul, fired rubber bullets at protests.
Bagram includes a prison for Afghans detained by Nato forces.----
Tags: death to america, because, of, burnt, koran, lol, silly, muslims, protests, afghanistan
Location: Afghanistan (load item map)
Marked as: approved
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