The prime minister is to use a speech in Edinburgh to launch what he calls a positive vision for the union between Scotland and the rest of the UK.
David Cameron will argue that the current United Kingdom makes all its nations stronger, safer and richer.
A spokesman for First Minister Alex Salmond described Mr Cameron's views as a "threadbare case for an outdated union".
It comes as Mr Cameron is due to meet Mr Salmond for talks in Edinburgh.
Mr Cameron said the fight to save the union was now under way and as prime minister he would use all he has to win it.
He will tell an Edinburgh audience: "I think that the United Kingdom is better off together.
"Of course Scotland has to make this choice - but I'll be saying I hope you opt to stay in the United Kingdom.
"Together we're actually stronger. I think we have a fairer country, a better country, a richer
In: Regional News, Politics
Tags: UK, breakup, england, scotland, Cameron, stay, in, etc.
Location: Scotland, United Kingdom (UK/GB) (load item map)
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