At least four Nato soldiers were killed in separate incidents in eastern Afghansitan on Tuesday, Isaf said in a statements.
Isaf said three of the four died in a bombing; the fourth after an insurgent attack.
Isaf did not provide the exact location of the incidents and nationality of the soldiers.
The incident occurred as a British soldier was found dead in southern Afghanistan on Monday after he went missing from a compound in Helmand province.
Taliban claimed responsibility for the death.
The deaths bring the number of foreign forces killed in Afghanistan to 289 so far this year.
Foreign forces are to start handing over security responsibilities to Afghan forces this month.
US is to pull out 23,000 of its troops by the end of 2012.
It comes as the British Premier during his visit to Afghanistan on Tuesday said he would make a full announcement in the British parliament on Wednesday. Earlier reports said he is expected to order withdrawal of 500-800 troops by the end of 2012.
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